Asian Journal of Pharmaceutical Research

P. Muthukumaran ¹, P. Padmapriya ¹, S. Salomi ¹, R. Umamaheshwari ¹, P. Kalaiarasan ¹, C. Malarvizhi ¹

Affiliations
1 P.G. Department of Biochemistry, Meenakshi Chandrasekaran College of Arts and Science, Pattukkottai-614626, Thanjavur, Tamil Nadu, IN

Abstract

The leaf powder of Mimosa pudica, Psidium guajava and Ipomoea aquatica forsk leaves were investigated against different spices of Gram negative bacteria i.e Shigella sonnei, Pseudomonas aeruginosa, Salmonella typhi, Escherichia Coli and fungi are Aspergillums niger, Candida albicans. The screening was performed by standard disc diffusion method. The leaf extract exhibited the highest antibacterial activity against E. Coli with 15±3mm zone of inhibition and for fungi the leaf extract have more anti fungal activity on Aspergillus niger 14±1mm zone of inhibition.

Keywords

Anti Microbial Activity, Gram Negative Bacteria, Fungi, Disc Diffusion Method.

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P. Muthukumaran ¹, P. Shanmuganathan ¹, C. Malathi ¹

Affiliations
1 Meenakshi Chandrasekaran Arts and Science College, Dept. of Life Sciences, Pattukkottai-614626, Thanjavur, Tamilnadu, IN

Abstract

The study of free radicals and antioxidants in biology is producing medical revolution that promises a new age of health and disease management. The present study was performed to evaluate the in vitro antioxidant effect of the ethanolic extract of Mimosa pudica (Mimosaceae) against free radical damage by different standard methods such as DPPH (1,1-diphenyl-2-picrylhydrazyl), Nitric Oxide (NO), ABTS (2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid)) and Hydrogen peroxide free radical model. The test extract exhibited significant inhibition in Nitric oxide and DPPH free radical formation with IC50 values of 78.1±1.75 and 35.00±1.15 μg/ml respectively. Whereas in the cases of ABTS and Hydrogen peroxide free radicals IC50 values of 81.00±3.85 and 449.60±2.55 μg/ml. Out of these four free radicals the extract showed potent activity on Nitric oxide and DPPH, which is compared to that of ascorbic acid and rutin taken as standards.

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